Selective and broad spectrum amphiphilic small molecules to combat bacterial resistance and eradicate biofilms.
نویسندگان
چکیده
Rationally designed amphiphilic small molecules selectively kill drug-sensitive and drug-resistant bacteria over mammalian cells. The small molecules disperse preformed biofilms and reduce viable bacterial count in the biofilms. Moreover, this class of membrane-active molecules disarms the development of bacterial resistance.
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عنوان ژورنال:
- Chemical communications
دوره 51 71 شماره
صفحات -
تاریخ انتشار 2015